Which of the following criteria is used by EPA in establishing pesticide tolerances?

The correct criteria used by the EPA in establishing pesticide tolerances is based on the toxicity of the pesticide and its breakdown products. This factor is crucial because it helps ensure that any residue left on food or in the environment is at levels that are safe for human health and the ecosystem. The EPA conducts extensive risk assessments to evaluate both acute and chronic toxicity associated with pesticides and their metabolites, considering their potential effects on different populations, including children and sensitive groups.

This focus on toxicity ensures that the tolerances set are based on sound scientific data regarding how the substances behave in the body, their potential harmful effects, and their breakdown into less harmful or more toxic substances over time. By analyzing these factors, the EPA aims to protect public health and the environment while allowing for the agricultural use of pesticides that are deemed safe within established tolerances.